What is self Immolative?
Self-immolative linkers, or spacers, are covalent groups, which have the role of cleavaging two bonds between a protector group and a drug, in the case of drug delivery systems, after a stimuli. The cascade of reactions allows to control the release of the drug.
How do dendrimers work drug delivery?
Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach.
How do dendrimers work?
In the different methods, dendrimer grows outward from a multifunctional core molecule. The core molecule reacts with monomer molecules containing one reactive and two dormant groups, giving the first-generation dendrimer. Then, the new periphery of the molecule is activated for reactions with more monomers.
Are dendrimers nanotechnology?
Dendrimers fall under the broad heading of nanotechnology, which covers the manipulation of matter in the size range of 1-100 nanometers (one million nanometers equal one millimetre) to create compounds, structures and devices with novel, pre-determined properties.
What is self immolation in chemistry?
Self-Immolative Chemistry is based on the cascade of disassembling reactions triggered by the adequate stimulation and leading to the sequential release of the smaller constituent elements.
What are the types of dendrimers?
2.1. Polyamidoamine (PAMAM) dendrimers.
Are dendrimers hydrophobic?
The internal architecture of a dendrimer is usually hydrophobic due to hydrophobic interactions and hydrogen bond formations and is suitable for encapsulating hydrophobic drugs/bio-actives (Medina and El-Sayed, 2009).
Where are dendrimers used?
Due to their size, dendrimers are used in nanomedicine research. They are found to be useful as delivery or carrier systems for drugs and genes, but studies have shown that some dendrimers have medicinal uses of their own, mostly due to their antifungal, antibacterial and cytotoxic properties [5,6].
Which is the example of dendrimer?
Examples of several types of dendrimers include those which have immense applications in drug delivery including poly(amidoamine) (PAMAM) dendrimers, poly(propylene imine) (PPI) dendrimers, polyether-copolyester (PEPE) dendrimers, PEGylated dendrimers, peptide dendrimers, etc.
How is dendrimer different from a polymer?
Dendrimers are hyperbranched macromolecules having a perfectly defined and highly functionalized repetitive structure. In contrast to all the other types of polymers, they are not synthesized by polymerization reactions but step by step (‘layer after layer’), which allows a perfect control of their structure.
What is the major issue with dendrimers?
These molecules have two major drawbacks: low hydrosolubility and high nonspecific toxicity. Hence, the use of dendrimers is a promising strategy [70,71,72,73].
What are some desirable features of dendrimers for drug delivery?
[23] Unlike traditional polymers, dendrimers have received considerable attention in biological applications due to their high water solubility,[24] biocompatibility,[25] polyvalency[12] and precise molecular weight. [26] These features make them an ideal carrier for drug delivery and targeting applications.